These tumors are difficult to treat because they do not respond to hormone-based therapies used for other types of breast cancer. They also tend to be more aggressive and have a higher mortality rate than other types of breast cancer.
Mendonca will present the new study at the annual meeting of the American Society for Pathology during the Experimental Biology (EB) 2022 meeting, which will be held April 2-5 in Philadelphia.
“The fact that cardamonin has been used for centuries as a spice and more recently as a supplement suggests that its consumption is safe and may offer health benefits.‘ Mendonca said.
“Our study shows that cardamonin has the potential to improve cancer therapy without as many side effects as other chemotherapeutic agents.. “
For the new study, the researchers investigated how cardamonin affects the expression of the programmed cell death ligand 1 (PD-L1) gene, which is found in tumor cells. PD-L1 is overexpressed during breast cancer progression and plays an important role in helping breast cancer cells evade the body’s immune system.
The researchers used two genetically different triple-negative breast cancer cell lines – one derived from women of African American descent and the other from women of European descent. (White skin). They found that treatment with cardamonin reduced cell viability in a dose-dependent manner in both cell lines.
It also decreased PD-L1 expression in Caucasian but not African American cell lines, suggesting that cells from different races may respond differently to cardamonin due to differences in genetic differences between races.
“Mendonca said this is the first study to describe the inhibitory effect of cardamonin on the expression of PD-L1, which has been implicated in the treatment of triple-negative breast cancer. microenvironment between African-Americans and non-African Americans. “
The researchers caution that the study is still ongoing. They plan to do more studies in both cells and animals to confirm the compound’s effectiveness before it is tested in humans. They also wanted to explore other possible mechanisms involved in cardamonin’s anticancer properties.