This study is the first to observe ovulatory dysfunction without disrupting the menstrual cycle during the pandemic.
Jerilynn C. Prior, MD, FRCPC, Professor of Endocrinology, said: “These silent ovulatory disorders may explain why so many women who are not using hormonal forms of birth control report having an early or unexpected periods in the days following the COVID-19 vaccine”. at the University of British Columbia in Vancouver, Canada.
Research on ovulation according to the menstrual cycle
Previously, and colleagues compared two independent, similarly designed studies 13 years apart: the Menstrual Ovulation (MOS) Study, which was performed on a group of 301 women since 2006 -2008, and MOS2, studied 112 women during a pandemic. Both studies included menstruating women aged 19-35 years who were not using combined or systemic hormonal contraceptives.
The first MOS was used as a control to compare with the experience of the MOS2 cohort during the pandemic. All participants in both studies completed comprehensive health, reproductive and lifestyle questionnaires and were asked to keep a daily diary of their menstrual cycles and overall life experiences.
For MOS2, ovulation was recorded using validated quantitative basal temperature. The researchers will confirm the MOS2 hormone characteristics using progesterone concentrations in saliva. For the MOS cohort, the researchers assessed ovulation by measuring the level of progesterone in the urine.
Nearly two-thirds of the women participating in the COVID-19 study did not ovulate normally, Before said. Women who experience a brief luteal phase, in which an egg is released without enough time since ovulation for pregnancy to occur, or ovulate, meaning no egg is released.
Meanwhile, the MOS study found that only 10% of women had an ovulatory disorder. The MOS2 and MOS studies showed similar body weight, body mass index values, menstrual cycle, and flow length. Thus, women in MOS2 show no obvious signs of reproductive disruption.
The Menstrual Cycle Diary © for MOS2 analyzes showed anxiety, depression, frustration, (overall negative mood), perceived external stress, sleep problems, and headaches. significantly increased compared to MOS.
“By comparing the two studies, and in particular their daily diaries, we can infer that the life disruption of the SARS-CoV2 pandemic causes silent ovulation in most of the women. Regular menstrual cycles – provide a unique experiment by nature,” says Prior.