. It can be biocompatible based on in-vitro cytotoxicity studies.
The researchers’ main aim was to reduce toxicity of the snake venom without losing its antimicrobial property. For that, the scientists truncated the snake venom peptide and eliminated the toxic part of snake venom and further stitched helical short peptide at N-terminus (the end with a free amino group) for the smooth entry of the newly designed therapeutic inside the bacterial cell.
Anti-microbial Properties of Snake Venom
The invented peptide also holds the potential to be developed into a marketable pharmaceutical product, said researchers.
The invented antimicrobial peptide SP1V3_1 holds the potential to be developed into a marketable pharmaceutical product, as and when it passes the requisite trials,” said Dr. Surajit Ghosh, Professor, Department of Bioscience & Bioengineering and Smart Healthcare Department, IIT Jodhpur, in a statement.
“The peptide can therapeutically be implemented as a component of an ointment (alone or in combination with other drugs/peptides) for wound disinfection and healing, as an injectable/oral drug for systemic administration, or as an aerosolized formulation to treat a wide range of respiratory bacterial pathogens,” he added.
- Predicting antibacterial activity from snake venom proteomes – (https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226807)