Using Polysubstance During Pregnancy | CDC

Our work

CDC’s National Center for Birth Defects and Developmental Disabilities (NCBDDD) works to address substance use during pregnancy. NCBDDD also works to improve care for those affected and their families. CDC does this through the following activities:

  • Collect and analyze data on substance exposure during pregnancy, the impact of evidence-based programs, and the occurrence of negative neonatal outcomes
  • Implement programs to inform policy for practices and system changes
  • Work with partners to develop and implement evidence-based interventions and clinical guidelines for maternal and neonatal care
  • Conduct communication activities to raise awareness and timely share new findings

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Multiple substance use during pregnancy: Importance of screening, patient education, and harm reduction mainstreaming.
Addiction to Drugs and Alcohol 2023;247:109872. DOI: 10.1016/j.drugalcdep.2023.109872
Ban A, D’Angelo DV, Salvesen von Essen B, Denny CH, Miele K, Dunkley J, Baillieu R, Kim SY.
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Systematic Review: Estimated Prevalence of Multiple Substances Reported During Pregnancy, USA, 2009–2020
Journal of Maternal Child and Health 2023; DOI: 10.1007/s10995-023-03592-w
Tran EL, Anh LJ, Park Y, Denny CH, Kim SY.
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Alcohol and other drug use in pregnant women 12–44 years of age – United States, 2015–2018
Weekly reporting of morbidity and mortality; August 7, 2020; 69(31): 1009-1014
Mr. LJ, Bennett C, Denny CH, Honein MA, Gilboa SM, Kim SY, Guy GP, Tran EL, Rose CE, Bohm MK, Boyle CA.
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More information

firstBrother LJ, Bennett C, Denny CH, et al. Alcohol and other drug use in pregnant women 12–44 years of age – United States, 2015–2018. MMWR Morb Mortal Wkly Rep 2020; 69(31): 1009-1014.
2Ko JY, Coy KC, Haight SC, et al. Characteristics of cannabis use during pregnancy – eight states, Pregnancy Risk Assessment Surveillance System, 2017. MMWR Morb Mortal Wkly Rep 2020; 69(32): 1058-1063.
3Jarlenski M, Barry CL, Gollust S, et al. Substance use among U.S. women of reproductive age using opioids for non-medical reasons. Am JP Public Health 2017; 107(8):1308-1310.
4Patrick SW, Dudley J, Martin PR, et al. Prescription opioid epidemic and neonatal outcomes. Pediatrics 2015;135(5):842–850.


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